Neuropharmacology

Neurofilament-Light Chain as Biomarker of Neurodegenerative and Rare Diseases With High Translational Value

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Neurofilament-Light Chain as Biomarker of Neurodegenerative and Rare Diseases With High Translational Value Read More »

CD8 + T-cells Infiltrate Alzheimer’s Disease Brains and Regulate Neuronal- And Synapse-Related Gene Expression in APP-PS1 Transgenic Mice

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CD8 + T-cells Infiltrate Alzheimer’s Disease Brains and Regulate Neuronal- And Synapse-Related Gene Expression in APP-PS1 Transgenic Mice Read More »

Transgene integration causes RARB downregulation in homozygous Tg4-42 mice.

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Transgene integration causes RARB downregulation in homozygous Tg4-42 mice. Read More »

The Leukotriene Receptor Antagonist Montelukast Reduces Alpha-Synuclein Load and Restores Memory in an Animal Model of Dementia with Lewy Bodies.

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The Leukotriene Receptor Antagonist Montelukast Reduces Alpha-Synuclein Load and Restores Memory in an Animal Model of Dementia with Lewy Bodies. Read More »

Plasma pharmacokinetic and metabolism of [18F]THK-5317 are dependent on sex.

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Plasma pharmacokinetic and metabolism of [18F]THK-5317 are dependent on sex. Read More »

Effector function of anti-pyroglutamate-3 Aβ antibodies affects cognitive benefit, glial activation and amyloid clearance in Alzheimer’s-like mice.

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Effector function of anti-pyroglutamate-3 Aβ antibodies affects cognitive benefit, glial activation and amyloid clearance in Alzheimer’s-like mice. Read More »

Characterization of the visceral and neuronal phenotype of 4L/PS-NA mice modeling Gaucher disease.

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Characterization of the visceral and neuronal phenotype of 4L/PS-NA mice modeling Gaucher disease. Read More »

Correction: Further investigation of phenotypes and confounding factors of progressive ratio performance and feeding behavior in the BACHD rat model of Huntington disease.

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Correction: Further investigation of phenotypes and confounding factors of progressive ratio performance and feeding behavior in the BACHD rat model of Huntington disease. Read More »

Hepatic and neuronal phenotype of NPC1−/− mice

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Hepatic and neuronal phenotype of NPC1−/− mice Read More »

Development of GMP-1 a molecular chaperone network modulator protecting mitochondrial function and its assessment in fly and mice models of Alzheimer’s disease.

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Development of GMP-1 a molecular chaperone network modulator protecting mitochondrial function and its assessment in fly and mice models of Alzheimer’s disease. Read More »

BACE1-cleavage of Sez6 and Sez6L is elevated in Niemann-Pick type C disease mouse brains.

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BACE1-cleavage of Sez6 and Sez6L is elevated in Niemann-Pick type C disease mouse brains. Read More »

Phosphorylation of different tau sites during progression of Alzheimer’s disease.

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Phosphorylation of different tau sites during progression of Alzheimer’s disease. Read More »

mTh1 driven expression of hTDP-43 results in typical ALS/FTLD neuropathological symptoms.

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mTh1 driven expression of hTDP-43 results in typical ALS/FTLD neuropathological symptoms. Read More »

Large-Scale Oral Treatment Study with the Four Most Promising D3-Derivatives for the Treatment of Alzheimer’s Disease.

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Large-Scale Oral Treatment Study with the Four Most Promising D3-Derivatives for the Treatment of Alzheimer’s Disease. Read More »

SEN1500, a novel oral amyloid-β aggregation inhibitor, attenuates brain pathology in a mouse model of Alzheimer’s disease.

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SEN1500, a novel oral amyloid-β aggregation inhibitor, attenuates brain pathology in a mouse model of Alzheimer’s disease. Read More »

Nortriptyline inhibits aggregation and neurotoxicity of alpha-synuclein by enhancing reconfiguration of the monomeric form.

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Nortriptyline inhibits aggregation and neurotoxicity of alpha-synuclein by enhancing reconfiguration of the monomeric form. Read More »

Glutaminyl Cyclase Inhibitor PQ912 improves cognition in mouse models of Alzheimer’s disease – studies on relation to effective target occupancy.

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Glutaminyl Cyclase Inhibitor PQ912 improves cognition in mouse models of Alzheimer’s disease – studies on relation to effective target occupancy. Read More »

Early start of progressive motor deficits in Line 61 α-synuclein transgenic mice.

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Early start of progressive motor deficits in Line 61 α-synuclein transgenic mice. Read More »

Early and progressive microstructural brain changes in mice overexpressing human α-Synuclein detected by diffusion kurtosis imaging.

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Early and progressive microstructural brain changes in mice overexpressing human α-Synuclein detected by diffusion kurtosis imaging. Read More »

Quantitative evaluation of orofacial motor function in mice: The pasta gnawing test, a voluntary and stress-free behavior test.

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Quantitative evaluation of orofacial motor function in mice: The pasta gnawing test, a voluntary and stress-free behavior test. Read More »