Neuropharmacology

Decreased Plasma Aβ in Hyperlipidemic APPSL Transgenic Mice is Associated with BBB Dysfunction.

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Decreased Plasma Aβ in Hyperlipidemic APPSL Transgenic Mice is Associated with BBB Dysfunction. Read More »

Brain cortical cholesterol metabolism is highly affected by human APP overexpression in mice.

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Brain cortical cholesterol metabolism is highly affected by human APP overexpression in mice. Read More »

Late-stage α-synuclein accumulation in TNWT-61 mouse model of Parkinson’s disease detected by diffusion kurtosis imaging.

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Late-stage α-synuclein accumulation in TNWT-61 mouse model of Parkinson’s disease detected by diffusion kurtosis imaging. Read More »

Diffusion Kurtosis Imaging Detects Microstructural Alterations in Brain of α-Synuclein Overexpressing Transgenic Mouse Model of Parkinson’s Disease: A Pilot Study.

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Diffusion Kurtosis Imaging Detects Microstructural Alterations in Brain of α-Synuclein Overexpressing Transgenic Mouse Model of Parkinson’s Disease: A Pilot Study. Read More »

Multigram Synthesis and in Vivo Efficacy Studies of a Novel Multitarget Anti-Alzheimer’s Compound

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Multigram Synthesis and in Vivo Efficacy Studies of a Novel Multitarget Anti-Alzheimer’s Compound Read More »

Long-term treatment of aged Long Evans rats with a dietary supplement containing neuroprotective peptides (N-PEP-12) to prevent brain aging: effects of three months daily treatment by oral gavage

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Long-term treatment of aged Long Evans rats with a dietary supplement containing neuroprotective peptides (N-PEP-12) to prevent brain aging: effects of three months daily treatment by oral gavage Read More »

Influence of Lentiviral β-Synuclein Overexpression in the Hippocampus of a Transgenic Mouse Model of Alzheimer’s Disease on Amyloid Precursor Protein Metabolism and Pathology

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Influence of Lentiviral β-Synuclein Overexpression in the Hippocampus of a Transgenic Mouse Model of Alzheimer’s Disease on Amyloid Precursor Protein Metabolism and Pathology Read More »

L-type calcium channel blockers and substance P induce angiogenesis of cortical vessels associated with beta-amyloid plaques in an Alzheimer mouse model

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L-type calcium channel blockers and substance P induce angiogenesis of cortical vessels associated with beta-amyloid plaques in an Alzheimer mouse model Read More »

Alzheimer’s Therapeutics Targeting Amyloid Beta 1 – 42 Oligomers I: Abeta42 Oligomer Binding to Specific Neuronal Receptors Is Displaced by Drug Candidates That Improve Cognitive Deficits

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Alzheimer’s Therapeutics Targeting Amyloid Beta 1 – 42 Oligomers I: Abeta42 Oligomer Binding to Specific Neuronal Receptors Is Displaced by Drug Candidates That Improve Cognitive Deficits Read More »

Tracking of Magnetite Labeled Nanoparticles in the Rat Brain Using MRI

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Tracking of Magnetite Labeled Nanoparticles in the Rat Brain Using MRI Read More »

Neuroinflammation and related neuropathologies in APPSL mice: further value of this in vivo model of Alzheimer’s disease

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Neuroinflammation and related neuropathologies in APPSL mice: further value of this in vivo model of Alzheimer’s disease Read More »

Time course and progression of wild type a-Synuclein accumulation in a transgenic mouse model.

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Time course and progression of wild type a-Synuclein accumulation in a transgenic mouse model. Read More »

Commentary to the recently published review “Drug pipeline in neurodegeneration based on transgenic mice models of Alzheimer’s disease” by Li, Evrahimi and Schluesener. Ageing Res. Rev. 2013 Jan;12(1):116-40.

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Commentary to the recently published review “Drug pipeline in neurodegeneration based on transgenic mice models of Alzheimer’s disease” by Li, Evrahimi and Schluesener. Ageing Res. Rev. 2013 Jan;12(1):116-40. Read More »

In Vivo and Ex Vivo Imaging of Amyloid-ß Cascade Aggregates with a Pronucleon™ Peptide.

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In Vivo and Ex Vivo Imaging of Amyloid-ß Cascade Aggregates with a Pronucleon™ Peptide. Read More »

CaV1.2 calcium channel expression in reactive astrocytes is associated with the formation of amyloid-β plaques in an Alzheimer’s disease mouse model.

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CaV1.2 calcium channel expression in reactive astrocytes is associated with the formation of amyloid-β plaques in an Alzheimer’s disease mouse model. Read More »

The bivalent ligand approach as a tool for improving the in vitro anti-Alzheimer multitarget profile of dimebon.

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The bivalent ligand approach as a tool for improving the in vitro anti-Alzheimer multitarget profile of dimebon. Read More »

Increased Efflux of Amyloid-β Peptides through the Blood-Brain Barrier by Muscarinic Acetylcholine Receptor Inhibition Reduces Pathological Phenotypes in Mouse Models of Brain Amyloidosis.

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Increased Efflux of Amyloid-β Peptides through the Blood-Brain Barrier by Muscarinic Acetylcholine Receptor Inhibition Reduces Pathological Phenotypes in Mouse Models of Brain Amyloidosis. Read More »

Impact of ApoB-100 expression on cognition and brain pathology in wild-type and hAPPsl mice.

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Impact of ApoB-100 expression on cognition and brain pathology in wild-type and hAPPsl mice. Read More »

Prion-like behaviour and tau-dependent cytotoxicity of pyroglutamylated amyloid-β.

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Prion-like behaviour and tau-dependent cytotoxicity of pyroglutamylated amyloid-β. Read More »

Elevated Levels of Soluble Total and Hyperphosphorylated Tau Result in Early Behavioral Deficits and Distinct Changes in Brain Pathology in a New Tau Transgenic Mouse Model.

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Elevated Levels of Soluble Total and Hyperphosphorylated Tau Result in Early Behavioral Deficits and Distinct Changes in Brain Pathology in a New Tau Transgenic Mouse Model. Read More »